Work

Histomorphological changes in the rat cerebral cortex following long-term caffeine consumption

Year: 2025

Type: article

Abstract: Investigating the effects of coffee and caffeine on the frontal cortex is essential for understanding how these widely consumed dietary compounds influence higher cognitive functions such as decision-making, behavioral regulation, and impulse control. Caffeine, as a psychoactive stimulant, can impact neuroplasticity and neuronal health, potentially leading to structural alterations in brain regions associated with executive functions. These changes may manifest in histomorphological alterations such as neuronal loss, synaptic density changes, or modifications in glial cell activity, which in turn could influence behavioral outcomes and cognitive performance. Understanding these effects can inform recommendations on caffeine consumption and guide future research into therapeutic strategies targeting the frontal cortex.

Source: Fìzìologìčnij žurnal

DOI: 10.15407/fz71.03.073

Authors: T.G. Turytska, V.P. Lyashenko, S.M. Lukashov, E.A. Lukyanetz, G.G. Chaus

Institutions: Dnipro State Medical University, Sumy State Pedagogical University named after A. S. Makarenko, Bogomoletz Institute of Physiology, Communal Institution of Higher Education «Dnipro Academy of Continuing Education» of Dnipropetrovsk Regional Council

Language: English

Topic: Coffee research and impacts

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

OpenAlex ID: W4411126119

FWCI:

Cites: 19

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Related to: 10