Work

Contractile Activity of Isolated Preparations of the Rat Portal Vein Under the Influence of Acetylcholine and L-arginine

Year: 2025

Type: article

Abstract: In acute experiments on rats, using the strain gauge method, the effect of acetylcholine and L-arginine on the smooth muscles of isolated preparations of the portal vein (PV) of the rat liver were investigated. Acetylcholine (1х10(-4) M and L-arginine (5.6х10(-4) M caused contraction of PV with intact endothelium. Deendothelization of the preparations by saponin (1 mg/ ml) led to decrease in the amplitude of contraction under the influence of the studied substances. The results obtained indicate an endothelium-dependent contraction of PV under the influence of acetylcholine and L-arginine, as well as the probable involvement of nitric oxide transformation products of endothelial origin in inducing such reaction.

Source: Fìzìologìčnij žurnal

DOI: 10.15407/fz71.03.097

Authors: O.M. Pasichnichenko, P.I. Yanchuk, M.Yu. Makarchuk

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411126402

FWCI:

Cites: 10

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Related to: 10