Year: 2025
Type: article
Abstract: Nitroimidazoles are five-membered heterocyclic ring systems in which the ‘’nitro’’ group is appended to either carbon 2 (benznidazole), 4 (pretomanid) or 5 (fexinidazole) of the imidazole ring. This compound class has shown broad pharmacological applications in the field of infectious diseases, providing drug substrates and/or hits against diseases such as tuberculosis, malaria, Chagas disease, sleeping sickness, leishmaniasis, giardiasis, and trichomoniasis. In this review, we have summarized hits, as well as clinically approved nitroimidazole based compounds against several tropical infectious diseases of clinical relevance. With the increasing antimicrobial drug resistance, and the dire need for new anti-infective agents, this review may act as a handy resource for researchers involved in anti-infective drug discovery.
Source: Discover Chemistry.
Institution: North-West University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funder: National Research Foundation
Award: G2934065332
OpenAlex ID: W4411126555