The effect of dark deprivation on the dynamics of body weight and the level of Klotho protein in the blood of animals
Year: 2025
Type: article
Abstract: The effect of 30-day dark deprivation (light-dark mode 24/0 h) on the dynamics of body weight and the level of Klotho protein in the blood of 4-month-old white mongrel female rats was studied. It was found that prolonged dark deprivation is accompanied by an increase in animal body weight against the background of a statistically significant decrease in the level of melatonin and Klotho protein in blood serum. It is a marker of premature aging. Melatonin had a protective effect on the body of animals, contributed to a decrease in body weight against the background of an increase in the content of Clotho protein in blood serum.
Authors: Larisa I. Kondakova, Victoria V. Bagmetova, Viktor S. Sirotenko, Tatyana S. Smirnova
Institution: Volgograd State Medical University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411126936