Direct vagal input to the gastrointestinal tract and other viscera: Re-definition of autonomic neuroscience or experimental artifacts?
Year: 2025
Type: review
Abstract: The canonical autonomic nervous system pathway to peripheral targets consists of two neurons in series, i.e., preganglionic and postganglionic. However, several recent reports claim a direct innervation of some sub-diaphragmatic organs by neurons of the vagal dorsal motor nucleus without intercalated postganglionic neurons. The aim of this minireview is to summarize these studies e.g. on direct vagal preganglionic innervation of Brunner's glands, liver and spleen and to critically discuss their unorthodox findings and discrepancies with previous literature. We conclude that rigorous re-evaluation by complementary state-of-the-art strategies is obligatory.
Source: Autonomic Neuroscience
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Awards: G4546073948, Integration of Lepr circuits for thermoregulation and energy status, Neural mechanisms controlling food intake and body weight after bariatric surgery, Metabolic Changes: Connecting temperature sensing neurons to sympathetic adipose tissue stimulation, Integrated Endocrine and Metabolic Research Training
OpenAlex ID: W4411127564