Work

Derivation of induced pluripotent stem cell TUSMi012-A from a 54-year-old Chinese Han with gliocytoma

Year: 2025

Type: article

Abstract: A 54-year-old male gliocytoma patient donated peripheral blood mononuclear cells (PBMCs). These cells were reprogrammed using a non-integrating Sendai Virus with OKSM (OCT3/4, SOX2, KLF4, and c-MYC) transcription factors. The resulting iPSCs showed pluripotency markers via immunocytochemistry, maintained a normal karyotype, and could differentiate into three germ layers in vitro. This iPSC line is a valuable tool for studying gliocytoma pathogenesis and developing treatments.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2025.103753

Authors: Jiqiang Ma, Zhongwei Zhuang, Cheng Yang, Bei Zhang, Kuiming Zhang

Institutions: Tongji University, Shanghai East Hospital

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360