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Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Year: 2025
Type: article
Abstract: ABSTRACT In this study, novel thiosemicarbazone derivative molecules ( 5a–j ) were synthesized. The characterization of the synthesized molecules was carried out using 1 H–, 13 C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The hCA I II, and AChE were efficiently inhibited by synthesized thiosemicarbazone derivatives, with Ki values in the range of 0.293–1.666 µM for hCA I, 0.298–1.332 µM for hCA II, and 52.51–138.63 µM for AChE, respectively. Finally, the sensor properties of the synthesized thiosemicarbazone derivatives were investigated. The newly synthesized thiosemicarbazone derivative molecules exhibited high selectivity towards Pb 2+ ions. The sensor prepared with 5a from these molecules had a Nernstian behavior of 28.8 ± 1.5 mV/decade and a low detection limit of 2.86 × 10 −6 M in a wide concentration range of 1.0 × 10 −1 –1.0 × 10 −5 M. The newly proposed sensor also had a wide pH working range (5.0–10.0), a very fast response time (5 s), and good reproducibility. The newly fabricated sensors were used as indicator electrodes for the potentiometric titration of Pb 2+ ions with ethylenediaminetetraacetic acid (EDTA) and were successfully applied for the determination of Pb 2+ ion content in different water samples.
DOI: 10.1002/bab.70001
Language: English
Open Access status: hybrid
Estimated APC paid: $3,470
OpenAlex ID: W4411131179
FWCI: 1.274
Cites: 54
Cited by: 5
Related to: 10