Work

Multiple aseptic abscesses and pulmonary involvement in a child with Behcet’s disease phenotype: a case report

Year: 2025

Type: article

Abstract: Background: Behcet's disease (BD) is a lifelong multi-systemic vasculitis disorder that can affect almost any organ. The frequency of involvement of each organ varies depending on demographic and geographical factors. The commonly affected systems include mucosal, articular, ocular, vascular, neurological, and gastrointestinal. Common gastrointestinal manifestations include mucosal ulcers, hemorrhage, and perforation while other phenotypes are very rare. Case presentation: We describe the case of a 3-year-old boy suffering from BD phenotype with multiple aseptic abscesses (AAs) and interstitial lung disease. Over the past four years since onset, the boy has presented a series of symptoms, including fever, skin necrosis, multiple ulcers in the intestines, multiple aseptic abscesses in the spleen, interstitial lung disease and an isolated abscess in the gastric wall. Through a regimen involving steroids, mercaptopurine, thalidomide endoscopic drainage of the gastric wall abscess, the child's condition has been effectively managed and improved. Conclusion: To our knowledge, this is the first reported case of BD phenotype with a gastric wall abscess treated with endoscopic drainage and steroids. Multiple AAs and interstitial lung disease may be the early signs of a BD phenotype in childhood which can respond effectively to glucocorticoids.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2025.1550551

Authors: Yucan Zheng, Guiping Kong, Hongmei Guo, Zhifeng Liu, Kunlong Yan

Institutions: Nanjing Children's Hospital, Second Affiliated Hospital of Nanjing Medical University

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801