Evaluation of the results of conservative treatment of patients with distal forms of atherosclerosis of the arteries of the lower extremities based on computer capillaroscopy
Year: 2025
Type: article
Abstract: Introduction. The choice of treatment tactics for patients with obliterating atherosclerosis of the arteries of the lower extremities is an urgent problem of vascular surgery, which has great medical and social significance. In case of OAANK stage IIA, conservative therapy is preferable. Aim. To study the results of using two conservative treatment regimens (sulodexide and sulodexide followed by pentoxifylline) in patients with distal atherosclerosis of the arteries of the lower extremities based on computer capillaroscopy. Materials and methods. The microcirculatory bed was assessed using computer capillaroscopy before and after treatment in patients. The results of conservative treatment of patients with distal atherosclerosis of the lower extremities were studied using computer capillaroscopy in 135 patients with obliterating atherosclerosis of the arteries of the lower extremities with stage IIA. The patients were divided into two groups, one group of patients received conservative treatment with sulodexide, the second group – combined conservative treatment with sulodexide (Thrombolix Pro®) and subsequent therapy with pentoxifylline (Trental®). Results and discussion. The results of the study showed that there is a statistically significant increase in the number of functioning linear capillaries and capillaries by area after conservative therapy with two different treatment regimens. At the same time, in the group using combined treatment (Thrombolix Pro® and continuation of Trental® therapy) the changes are more pronounced: the number of linear working capillaries was 5.5 ± 2.4 pcs. per 1 mm2, and the number of working capillaries by area was 16.7 ± 5.3 pcs. per 1 mm2. Conclusions. In the distal form of obliterating atherosclerosis of the arteries of the lower extremities of the femoral-popliteal-tibial segment with stage IIA, changes in the microcirculatory bed are noted after treatment in both groups of patients, but more pronounced changes after treatment according to the Thrombolix Pro® regimen and continuation of Trental® therapy.
DOI: 10.21518/akh2025-035
Institution: Samara State Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411133192