Work

CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols

Year: 2025

Type: article

Abstract: An efficient photoinduced and metal‐free method for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU‐system as a hydrogen bond acceptor (HBA) catalyst in the presence of water (H2O) is reported. This protocol allows for selective functionalization of alcohols with a broad substrate scope, demonstrating yields up to 88% in 36 examples. Systematic computational analysis using DFT calculations reveals insights into the mechanism by identifying the key intermediates assembled via intermolecular hydrogen bond between DBU‐CO2 adduct and alcohol. This strategy opens new avenues for efficient alkylation of ordinary alcohols, offering an environmentally friendly approach to complex molecular synthesis.

Source: Advanced Science

DOI: 10.1002/advs.202507490

Authors: Zeyu Zhang, Zongchang Han, Yuhao Shang, Han‐Shi Hu, Jun Li, Chanjuan Xi

Institutions: Tsinghua University, Nankai University, State Key Laboratory of Elemental Organic Chemistry

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Climate action

Open Access status: gold

Estimated APC paid: $6,730