A comparison of renal cell carcinoma with tumor thrombus across North America, Central/South America, and South Korea
Year: 2025
Type: article
Study design: Observational Study
Abstract: PURPOSE: With multi-institutional collaboration, the purpose of this study was to analyze geographical differences of renal cell carcinoma with tumor thrombus between patients in North America, Central/South America, and South Korea. MATERIALS AND METHODS: Patients with renal cell carcinoma and a tumor thrombus who underwent nephrectomy plus thrombectomy were retrospectively analyzed. Patients were from North America, Central/South America, and South Korea. All comparisons were done based on the region where a patient had their surgery and follow-up. Chi-squared test, analysis of variance, Kaplan-Meier survival with log-rank test, and Cox regression analysis were used. RESULTS: A total of 478 patients were included, 212 from North America, 209 from Central/South America, and 57 from South Korea. Of note, thrombus level was different using the Neves classification system between regions (p<0.001), with a greater thrombus level in Central/South America. Surgical approach differed, with laparoscopic cases done most often in Central/South America and robotic in North America (p<0.001). Tumor grade was lowest in South Korea (p<0.001) and stage (p<0.001) greatest in Central/South America. Overall survival was greater in South Korea compared to Central/South America (p=0.026). Cancer-specific survival was greater in South Korea relative to North America and Central/South America (p=0.026). CONCLUSIONS: Patients from North America, Central/South America, and South Korea diagnosed with renal cell carcinoma and tumor thrombus do not present the same and have different outcomes peri-/post-operatively. This includes important variables which have impacts on patient morbidity and mortality. Considering increased efforts on health equity in urology.
Authors: Maxwell Sandberg, Rachel Vancavage, Claudia Marie-Costa, Emily Ye, Mitchell Hayes, Justin Miller, Reuben Ben David, Kartik Patel, Kimberly Waggener, Brejjette Aljabi, SeokSoon Byun, Patricio García Marchiñena, Thiago Mourao, Charles Peyton, Reza Mehrazin, Philippe Spiess, Rafael Zanotti, Steven Chang, Stenio de Casio Zequi, Diego Abreu, Alejandro Rodriguez
Institutions: Atrium Health Wake Forest Baptist, Albany Medical College, Wake Forest University Health Sciences, Wake Forest University, Moffitt Cancer Center, University of South Florida, Icahn School of Medicine at Mount Sinai, University of Alabama at Birmingham, UAB Medicine, University of Alabama, Hospital Italiano de Buenos Aires, AC Camargo Hospital, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $323
OpenAlex ID: W4411134568