Work

Neurocutaneous melanosis in a pediatric patient with intraspinal hamartoma presentation

Year: 2025

Type: article

Abstract: Background Neurocutaneous melanosis (NCM) is a rare congenital syndrome involving melanocytic tumors in the central nervous system (CNS) in association with giant melanocytic nevi. Case presentation This case details a 10-year-old male with NCM, presenting with an intraspinal hamartoma. Computed tomography revealed spinal cord compression. Pathology confirmed that the cutaneous lesions were nevi and that the hamartoma exhibited pigmentation, with positive staining for S100, HMB-45, and Fontana-Masson. Conclusion This case illustrates the embryological link between CNS and skin melanocytic proliferation.

Source: Surgical and Experimental Pathology

DOI: 10.1186/s42047-025-00186-4

Authors: Camila Barbosa, Hercilio Fronza Junior, Simone Muller, Thiago Traesel, Bruna Louise Silva, Paulo Henrique Condeixa de França, Karina Munhoz de Paula Alves Coelho

Institutions: Hospital Municipal São José, Universidade do Estado de Santa Catarina, Universidade da Região de Joinville

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411136724

FWCI:

Cites: 10

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Related to: 10