Work

Stearic acid-modified hexavanadate vesicles loaded with hydroxy fatty acid esters synergistically improve obesity-related metabolic disorders and inflammation

Year: 2025

Type: article

Abstract: Obesity-driven insulin resistance and chronic inflammation present pressing therapeutic challenges, necessitating innovative strategies that target underlying metabolic dysregulation. Here, we report the development of stearic acid-modified hexavanadate (SA-V6) vesicles, a self-assembling nanoplatform engineered for efficient loading and delivery of Palmitic acid hydroxystearic acids (PAHSAs). In a high-fat diet (HFD)-induced murine obesity model, SA-V6/HFAE vesicles exhibited enhanced intestinal absorption, synergistically alleviating glucose-lipid metabolic disturbances via augmented insulin and glucagon-like peptide (GLP-1) secretion, as evidenced by improved glycemic control and normalized serum lipid profiles. Furthermore, the hybrid vesicles suppressed proinflammatory cytokine secretion in adipose tissue while activating the GPR120 and insulin signaling axis, a dual mechanism critical to restoring metabolic homeostasis. By integrating nanomaterial design with multifunctional bioactive cargo, this work establishes a promising therapeutic approach to address obesity-associated metabolic dysfunction and inflammation. The dual action of SA-V6/HFAE vesicles in enhancing insulin and GLP-1 secretion, alongside GPR120 pathway activation, highlights their potential as a translatable platform for precision management of complex metabolic disorders.

Source: Polyoxometalates

DOI: 10.26599/pom.2025.9140092

Authors: Pengyu Wu, Pengcheng Cui, Yingying Wang, Kun Chen

Institution: South China University of Technology

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Guangzhou Municipal Science and Technology Project