Work

CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis

Year: 2025

Type: article

Abstract: functional assays demonstrated the inhibitory effects of circYAP1 on osteosarcoma cell proliferation, invasion, and migration. Regarding the mechanism, circYAP1 acts as a competitive endogenous RNA (ceRNA) to sponge miR-135b-5p, whereas FRK is a direct target of miR-135b-5p. Finally, a tumor-suppressing role of circYAP1 was demonstrated in the orthotopic lung metastasis models. In conclusion, our data reveal a tumor-suppressing role of circYAP1 and circYAP1/miR-135b-5p/FRK axis in osteosarcoma, demonstrating potential therapeutic targets for osteosarcoma.

Source: iScience

DOI: 10.1016/j.isci.2025.112858

Authors: Mingrui Du, Xuesan Zhang, Menglin Cong, Chengkui Cai, Qingxiang Zhang, Haixia Xin, Lanbo Yang, Qingqing Geng, Mingfu Shang, Zheng Zhang, Le Shen, Shusen Tan, Kang Han

Institutions: Shandong University, Qilu Hospital of Shandong University, Affiliated Hospital of Shaanxi University of Chinese Medicine, Luoyang Orthopedic-Traumatological Hospital of Henan Province

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Medical and Health Science and Technology Development Project of Shandong Province, China National Funds for Distinguished Young Scientists, National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers

Awards: G296431121, G4302226885, G6746994547

OpenAlex ID: W4411139624

FWCI: 0.252

Cites: 46

Cited by: 1

Related to: 10