Work

Potential of stem cells in tissue and organ regeneration, current clinical trials

Year: 2025

Type: article

Abstract: Regenerative medicine, based on the use of stem cells (SC), represents one of the most promising areas of modern medicine. Objective: to explore the possibilities of using SC in the restoration of tissues and organs, as well as to analyze current clinical trials in this field. Material and methods. The article examines types of SC such as embryonic, pluripotent, and mesenchymal stem cells, and analyzes current clinical trials regarding their application. Results. The main focus is on the mechanisms of action of SC after transplantation, issues of their long-term safety, mechanisms of differentiation, and integration into the tissues of the body. Conclusion. Despite the progress made, the application of SC is associated with a number of unresolved issues, such as the risk of malignant transformation of cells and the possibility of virus transmission during allogeneic transplantation.

Source: Clinical Medicine (Russian Journal)

DOI: 10.30629/0023-2149-2025-103-2-85-91

Authors: A. A. Semakov, E. G. Sapego, E. D. Kirienkova, V. D. Soldatova, K. I. Sfieva

Institutions: North-Western State Medical University named after I.I. Mechnikov, Altai State Medical University, Ministry of Health of the Russian Federation, Sechenov University, Pirogov Russian National Research Medical University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411141943

FWCI:

Cites: 27

Cited by:

Related to: 10