Work

Mechanistic study of N-acetyltransferase 10 deficiency enhancing olaparib sensitivity in triple negative breast cancer by inhibiting RAD51 N4-acetylcytidine modification

Year: 2025

Type: article

Abstract: by promoting DSBs. Our findings illuminate a potential therapeutic strategy targeting NAT10 to enhance olaparib efficacy in TNBC.

Source: iScience

DOI: 10.1016/j.isci.2025.112860

Authors: Hui Li, Hao Wu, Siwei Li, Qin Wang, Guozheng Li, Xin Ma, Yajie Gong, Yijun Chu, Shengye Jin, Xi Chen, Xianyu Zhang, Da Pang

Institutions: Harbin Medical University, Third Affiliated Hospital of Harbin Medical University, Heilongjiang Academy of Medical Sciences, Second Affiliated Hospital of Harbin Medical University

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Harbin Medical University Cancer Hospital, Key Research and Development Program of Heilongjiang, National Natural Science Foundation of China

Awards: G1034258786, G1284204176, G2196688648, G4792388615, G7339167523, G8112620543, G8763278234

OpenAlex ID: W4411146789

FWCI: 2.18

Cites: 107

Cited by: 6

Related to: 10