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Colonic Diaphragm Disease Induced by Chronic Non-steroidal Anti-inflammatory Drug (NSAID)-Use Requiring Multiple Endoscopic Interventions: A Case Report

Year: 2025

Type: article

Abstract: Non-steroidal anti-inflammatory drug (NSAID)-induced colonic diaphragm disease is an uncommon yet significant cause of gastrointestinal symptoms. We present a case of a 51-year-old male with chronic NSAID use who developed abdominal pain, weight loss, and gastrointestinal bleeding. Imaging and endoscopy revealed a short, benign-appearing stricture in the ascending colon consistent with diaphragm disease. The patient required multiple endoscopic interventions, including lumen-apposing metal stent placement and balloon dilation, to relieve the obstruction. This case underscores the importance of recognizing NSAID-induced colonic pathology and highlights the role of advanced endoscopic techniques in managing complex strictures.

Source: Cureus

DOI: 10.7759/cureus.85621

Authors: Hasan Jaber, Fawzi Elias, Nader Al Souky, Obada Tayyem, Gebran Khneizer

Institutions: University of Kansas, The University of Texas Medical Branch at Galveston

Language: English

Topic: Esophageal and GI Pathology

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411149107