Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim of the study: Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent.The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence. Material and methods:The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.Results: Among 3,419 patients, MASLD was diagnosed in 24.2%.Lean MASLD was diagnosed in 11.3% of patients with MASLD.Independent predictors of lean MASLD were atherogenic dyslipidaemia (OR = 94.16,CI: 45.54-197.71,p < 0.0001), diabetes mellitus or prediabetes conditions (OR = 9.26, CI: 4.42-19.38,p < 0.0001) and hypertension (OR = 2.97, CI: 1.38-6.41,p = 0.0054).Conclusions: Lean MASLD is not a rare form of the disease, and in the lean MASLD group there are patients with a high rate of metabolic abnormalities which may significantly increase cardiovascular risk and the risk of MASLD progression.
Authors: Iwona Gorczyca-Głowacka, Łukasz Nawacki, Magdalena Kołomańska, Robert Mazurkiewicz, Marcin Niżnik, Krzysztof Ratnicki, Małgorzata Czerniak, Piotr Myrcha, Maciej Bękarski, Joao Rocha-Neves, Juliana Pereira-Macedo, Kryspin Mitura, Laura Kacprzak, Małgorzata Pajer, Piotr Richter, Kamil Rapacz, Maciej Sroczyński, Mateusz Szmit, Stanisław Głuszek
Institutions: Jan Kochanowski University, Ministry of Interior and Administration, Medical University of Warsaw, Universidade do Porto, Unidade Local de Saúde do Médio Ave, University of Siedlce, Jagiellonian University, University of Wrocław, Wroclaw Medical University, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Polish Academy of Sciences
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411157670