Puncture frequency, coagulopathy, and liver injury as independent risk factors for bleeding in acute diquat poisoning after enhanced blood purification therapy
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To identify independent risk factors for bleeding and propose preventive strategies in acute diquat poisoning (ADP) patients undergoing enhanced blood purification therapy (EBPT). METHODS: In this retrospective study, a total of 297 ADP patients (May 2022-April 2024) were categorized into a conventional treatment (n=124) and EBPT (n=173) groups according to their treatment regimens. Clinical data, coagulation/liver function, and bleeding events were compared between the two groups. Logistics regression analysis was applied to identify independent risk factors for bleeding. COX regression model was used to explore the risk factors affecting survival prognosis. Kaplan-Meier method was used to draw survival analysis curve. RESULTS: The EBPT group had a significantly higher bleeding incidence (45.05% vs. 4.23%, P<0.05), predominantly at puncture sites. Independent bleeding risk factors included puncture frequency, degree of poisoning, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), white blood cell count (WBC), elevated alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (P<0.05). Bleeding patients had a higher 28-day mortality rate (50.00% vs. 18.95%, P<0.05) and longer ICU stays. Cox analysis confirmed that ALT, puncture frequency, poisoning severity, and bleeding were significant survival predictors (P<0.05). CONCLUSION: EBPT increases bleeding risk in ADP patients, mainly due to procedural factors and organ dysfunction. Optimizing puncture techniques and closely monitoring coagulation and liver function may improve patient outcomes.
DOI: 10.62347/nysi3538
Author: Ting Zhang
Institution: Gansu Provincial Hospital of TCM
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411159130