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The Effectiveness of Ozonated Platelet Rich Plasma& Exercise as Pain Management for Baker’s Cyst Associated with Knee Joint Osteoarthritis

Year: 2025

Type: article

Abstract: ObjectivesBaker’s cyst is the most common cystic lesion around the knee joint, particularly prevalent in individuals with knee osteoarthritis, with an incidence rate reported between 10% and 41%. This study aimed to evaluate the clinical effectiveness of intralesional Ozonated Platelet-Rich Plasma (PRP) injections combined with exercise in managing Baker’s cyst associated with knee osteoarthritis. MethodsThis retrospective study included 24 patients (17 females and 7 males) treated at a private clinic in Kirkuk over an 18-month period (July 1, 2018 – December 31, 2019). All patients received a comprehensive clinical, radiological, and ultrasound assessment. PRP was prepared from autologous blood using a two-step centrifugation process and activated with ozone using a Longevity Resources EXT50 Ozone Generator. Following cyst aspiration, the first Ozonated PRP injection was administered under ultrasound guidance. Subsequent intra-cystic and intra-articular PRP injections were given every 4 weeks for four more sessions. Each intra-articular injection was accompanied by periarticular subcutaneous ozone infiltration. Patients also performed quadriceps-strengthening and calf-stretching exercises beginning three days after the first injection. ResultsThe mean patient age was 59 ± 8 years, with the majority aged between 50–59 years (n = 12, 50%) and 60–69 years (n = 7, 29%). A total of 21 patients (87.5%) demonstrated good to excellent clinical improvement in terms of pain relief and functional recovery following the treatment regimen. ConclusionIntralesional and intra-articular Ozonated PRP injections, combined with a structured exercise program and adjunctive ozone therapy, appear to be a safe and effective approach for managing Baker’s cyst associated with knee osteoarthritis.

Source: Iraq Medical Journal

DOI: 10.22317/imj.v9i1.1303

Authors: Hayder Ghali Wadi Algawwam, Abdullah Ahmed Mohammad, Iman Najdat, Huda Ihsan KhairuAllah, Safwat Abbas Ali Askar

Institutions: University of Baghdad, University of Kirkuk

Language: English

Topic: Periodontal Regeneration and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $125