Manual vs. Mechanical Ventilation in Respiratory Parameters of intubated Patients During cardiopulmonary Resuscitation; a Randomized Clinical Trial.
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Introduction: Ventilation and oxygen delivery during cardiopulmonary resuscitation (CPR) is of paramount importance. This study aimed to compare the effects of manual and mechanical ventilation on respiratory parameters of intubated patients during CPR. Methods: This randomized controlled clinical trial was conducted in 2024 on 61 intubated patients with neurological disorders admitted to the ICU of educational hospitals. Participants were allocated to either the intervention or the control group using block randomization with a block size of six. The intervention group received mechanical ventilation, while the control group received manual ventilation using bag valve mask (BVM). The effects of manual versus mechanical ventilation during CPR on key physiological and respiratory parameters, including venous blood gases (VBG), end tidal Co2 (ETCO₂), and peripheral oxygen saturation (SpO₂) were compared between groups. Statistical analyses were performed using SPSS version 21. Results: levels (P = 0.47) changes. However, PO₂ (P < 0.001), ETCO₂ (P < 0.05). and SpO₂ (P < 0.001) were more stable and consistently higher in patients receiving mechanical ventilation. Conclusion: levels did not significantly differ between the two ventilation methods, mechanical ventilation demonstrated superior efficacy in optimizing oxygenation (PO₂ and SpO₂) and regulating ETCO₂ levels.
Authors: Nastaran Lotfi, Ahmad Bagheri Moghaddam, Razieh Froutan, Hossein Nezami
Institution: Mashhad University of Medical Sciences
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411163685