Work

The role of proteomics and radioproteomics in biomarkers of liver HCC for di-agnosis, therapy and enhance interventional radiological treatments

Year: 2025

Type: article

Abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer and is highly malignant. Current diagnostic tests are blood, imaging and biopsy, with no useful predictive biomarker. Additionally, targeted therapies are unavailable, which hinders the potential for personalized therapy in HCC patients. Here, we discuss the limited studies conducted thus far to identify molecular targets for early detection and treatment of HCC, their limitations and future directions in this field. However, the integration of multi-omics analyses, such as genomics, proteomics, and phosphoproteomics, has provided valuable insights into the mechanisms and pathways underlying the disease.

Source: Cancer Reports and Reviews

DOI: 10.15761/crr.1000244

Author: Margaret Simonian

Institution: University of California, Los Angeles

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering