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Enzyme-catalyzed C(sp 3 )–H aminations for the highly enantioselective construction of chiral 2-oxazolidinones

Year: 2025

Type: article

Abstract: Engineered myoglobin variants were able to activate C(sp 3 )–H under mild conditions via mediated nitrene transfer and intramolecular cyclisation to form highly enantioselective 2-oxazolidinone and γ-lactams.

Source: RSC Advances

DOI: 10.1039/d5ra01905b

Authors: Hanzi Gao, Miao Li, Guojun Zheng

Institutions: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W4411179715

FWCI:

Cites: 40

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Related to: 10