Photothermal therapeutic effects and biosafety of a carbon nanoparticles–Fe( ii ) complex for triple-negative breast cancer
Year: 2025
Type: article
Abstract: . The therapeutic mechanisms and biosafety were also investigated. CNSI-Fe exhibits excellent photothermal conversion efficiency. CNSI-Fe had significant cytotoxicity against TNBC cells, and photothermal therapy (PTT) further enhanced its antitumor effects. The combination of CNSI-Fe and PTT treatments exhibited a more pronounced tumor-suppressive effect and longer survival time comparing to single modality treatment. Mechanistic studies indicated that PTT facilitated the entry of iron ions from CNSI-Fe into cancer cells, generating more hydroxyl radicals and significantly enhancing the ferroptosis. The haematological and serum biological parameters associated with the histopathological observations indicated that the side-effects of CNSI-Fe were low during PTT. Overall, we evidenced the synergistic effect of CNSI-Fe chemotherapy and PTT for TNBC treatment with low toxicity.
Source: RSC Advances
DOI: 10.1039/d5ra03041b
Authors: Yuanfang Huang, Kexin Tang, Guangfu Zeng, Huahui Yuan, Qian Xin, Yufeng Zhao, Ting Qu, Jinmei Yang, Cheng Zeng, Xian Wu, Zehui Gou, Ping Xie, Sheng-Tao Yang, Xiaohai Tang
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Awards: G5581265666, G8348544298
OpenAlex ID: W4411184658