Year: 2025
Type: article
Study design: Case Report
Abstract: A 43-year-old male patient presented with a progressively enlarging mass in his right lateral tibia over the course of one month. The mass measured 4 x 7 cm in size on examination. Aspiration of the lesion was performed, revealing 30 cc of dark blood, leading to an initial diagnosis of hematoma. Three months later, the mass had enlarged with mild pain. Physical examination revealed a 12 x 9 cm fluctuant mass on the right lateral lower leg, which was warmer than surrounding skin and tender upon palpation. Subsequent imaging was ambiguous, with a broad differential diagnosis consisting of expanding hematoma, abscess, neoplasm, and arteriovenous malformation (AVM). A biopsy was performed revealing pleomorphic cells consistent with an undifferentiated pleomorphic sarcoma (UPS). This case report highlights the challenges of diagnostic workup, management, and follow-up of an unusual presentation of a UPS.
Source: Cureus
DOI: 10.7759/cureus.85786
Authors: Kyle W Eaton, Emily Jagenburg, Arian Pakray, Vikram Kinni, Benjamin Pomerantz
Institutions: Henry Ford Health, Oakland University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411193779