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SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy

Year: 2025

Type: article

Abstract: This study uncovers critical features of SUMOylation in regulating Spike-mediated viral spread and pathogenesis, providing a potential broad-spectrum therapeutic target for drug development against emerging SARS-CoV-2 infection.

Source: Theranostics

DOI: 10.7150/thno.111256

Authors: Xinyu Wang, Gaowei Hu, Yupeng Shao, Zhongwei Dong, Lina Liu, Yixuan Wang, Yaxi Xie, Nuoya Yu, Caixia Zhu, Fang Wei, Yuping Jia, Yuyan Wang, Qiliang Cai

Institutions: Shanghai Medical College of Fudan University, Fudan University, Baoji City Central Hospital, Shanghai Jiao Tong University, Shandong Academy of Pharmaceutical Sciences

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4411195857

FWCI: 2.196

Cites:

Cited by: 3

Related to: 10