HIV-1 infection of macrophages differentially primes NK-cell cytotoxicity and proinflammatory cytokine production
Year: 2025
Type: article
Abstract: NK cells -a subset unique to HIV-1 infection- remained dysfunctional. These findings elucidate how HIV-1 alters macrophage-NK cell crosstalk and underscore the need for therapeutic strategies that enhance NK-cell cytotoxicity in efforts toward a functional HIV-1 cure.
Source: iScience
Authors: Leonore Mensching, Maya Beiersdorfer, Sebastian Schloer, Sandra Köllmann, Friederike Reinsberg, Benedetta Padoan, Pia Fittje, Timo Trenkner, Annika Zaayenga, Gloria Martrus, Maher Almahfoud, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Julian Schulze zur Wiesch, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Angelique Hoelzemer
Institutions: Leibniz Institute of Virology (LIV), University Medical Center Hamburg-Eppendorf, German Center for Infection Research, Universität Ulm, University Hospital Ulm, University of Tübingen, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Massachusetts Institute of Technology
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: Deutsches Zentrum für Infektionsforschung, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Hector Stiftung, National Institutes of Health, Horizon 2020 Framework Programme, European Research Council, National Institute of Allergy and Infectious Diseases, H2020 European Research Council
OpenAlex ID: W4411196134