Work

UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice

Year: 2025

Type: article

Abstract: spermatocytes. Proteomics analysis uncovered an extensive suite of meiosis- and chromosome segregation-associated proteins unexpressed in mouse spermatocytes lacking functional UBE2J2. Our findings suggest that UBE2J2 could possibly play a key role in SC disassembly, ensuring meiosis can proceed in the late pachynema during male germline cell development in mice, and serves as an essential factor in meiotic recombination and spermatogenesis.

Source: iScience

DOI: 10.1016/j.isci.2025.112878

Authors: Xiaochen Yu, Jie Cen, Yaxuan Zhang, Tongtong Li, Mingyu Zhang, Fei Gao, Hongbin Liu, Yongzhi Cao

Institutions: Shandong University, First Affiliated Hospital Zhejiang University, State Key Laboratory of Reproductive Medicine, Zhejiang University, Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Stem Cell and Reproductive Biology

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,240

Funders: Natural Science Foundation of Shandong Province, Taishan Scholar Foundation of Shandong Province, Taishan Scholar Project of Shandong Province, Major Scientific and Technological Innovation Project of Shandong Province, Natural Science Fund for Distinguished Young Scholars of Shandong Province, Key Technologies Research and Development Program, National Key Research and Development Program of China

Awards: G3297043547, G4489524862, G6437716435, G7551870325

OpenAlex ID: W4411196145

FWCI: 0.7

Cites: 57

Cited by: 1

Related to: 10