Work

Conservative approach for intra-amniotic Candida albicans colonisation. Case report and review of current evidence

Year: 2025

Type: article

Abstract: Objectives Intra-amniotic colonisation or infection caused by Candida albicans is rare. Given the shortage of reported cases, evidence on antifungal strategies and the choice of type and timing of delivery is limited. Case presentation We report a case of intra-amniotic colonisation by C. albicans in a pregnant woman with a previous history of cervical cerclage and candidal vaginosis at 25 weeks of gestational age (GA). The diagnosis was made following preterm premature rupture of membranes at GA 28 weeks and 6 days. Treatment was started with amphotericin B and was replaced by fluconazole due to an anaphylactic reaction. The persistence of C. albicans in the amniotic fluid after 24 days of treatment prompted the decision to plan an elective caesarean delivery at 32 weeks’ GA. The infant showed no signs of fungaemia and had an uneventful clinical course after 14 days of treatment with fluconazole. Conclusions Conservative management with intravenous fluconazole in pregnant women with intra-amniotic colonisation by C. albicans at early GA, can contribute to the prolongation of pregnancy while protecting the foetus from fungal disease.

Source: Case Reports in Perinatal Medicine

DOI: 10.1515/crpm-2024-0047