Thermogenesis and reduced lipid synthesis: one-anastomosis gastric bypass bariatric surgery 6-mo follow-ups in adipose tissue health context for type 2 diabetes
Year: 2025
Type: article
Abstract: Today, bariatric surgery remains the most effective instrument for weight loss, glycemic control, and type 2 diabetes combat. Bariatric surgery causes mild stimulation of ADSC proliferation and suppresses white adipogenesis. ADSC-derived adipocytes exhibited lipid droplet fragmentation, activation of thermogenesis, and inhibition of lipogenesis. Thus, enhanced ability of ADSC to proliferate and differentiate into thermogenic adipocytes with reduced activity of lipogenesis may support energy expenditure and prevent weight gain after bariatric surgery.
Authors: Iurii Stafeev, Margarita Agareva, Svetlana Michurina, Alina Tomilova, Ekaterina Shestakova, Anastasiya Voznesenskaya, Maria Sineokaya, Natalia Alekseeva, Maria Boldyreva, Elizaveta Ratner, Yelena Parfyonova, Marina Shestakova
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Russian Science Foundation
Award: G1184155020
OpenAlex ID: W4411197246