Work

Comprehensive approaches in AlzheimerÓ?s disease: from general aspects to stem cell therapy and antidiabetic use

Year: 2025

Type: article

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-ß and Tau protein in brain tissue.AD represents 80% of the cases of dementia worldwide, affecting more than 7.29 million people with an increase in incidence of 147.95% in the past 30 years.At present, conventional treatments for this condition remain limited, which has led to a significant increase in its incidence and prevalence.In this paper, we address general aspects regarding AD, from its pathophysiology, diagnostic methods, and its association with insulin resistance; as well as present treatments and new alternatives, specifically hypoglycemic agents, such as metformin, liraglutide and insulin; and neural stem cells.It is concluded that stem cell and antidiabetic treatments had positive results in preclinical studies, so more future studies are required to consider them safe in humans.

Source: Revista de Fomento Social

DOI: 10.24875/rmn.24000049