Assessment of the Physical Properties, Drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres
Year: 2025
Type: article
Abstract: Microspheres based transarterial chemoembolization is important for liver cancer treatment.UniPearls ® is a novel product of microspheres featuring a uniform particle size and independently developed in China.This study aimed to investigate the physical properties, drug loading and releasing ability, and biocompatibility of UniPearls ® .Various experiments were performed including: compression rupture, suspendability, simulated use, drug loading, drug releasing, cytotoxicity, mouse lymphoma assay (MLA), muscle implant, intradermal reaction, guinea pig maximization test (GPMT), and systemic toxicity.UniPearls ® or UniPearls ® extraction liquid was set as experimental group(s), while HepaSphere ® or related extraction liquid was set as control group(s).UniPearls ® showed no microsphere rupture after compression to 1 μm for 10 or 20 min, but some ruptures for 30 min, and microspheres were successfully suspended in a short time.In a 3D hepatic artery model, UniPearls ® exhibited no microsphere break, delivery block, shape change or unexpected catheter outflow during microspheres, benefiting from its satisfied physical properties, drug loadability, releasing ability and biocompatibility.
Authors: Fei Guo, Min Xu, Baosheng Ren, Fengxuan Han
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411198764