Work

Pd‐catalyzed CH Activation and Oxidative Annulation to Access N‐methoxy‐7H‐Chromenoquinolinones and N‐methoxyphenyl quinolinones

Year: 2025

Type: article

Abstract: The palladium‐catalyzed oxidative annulation of N‐methoxy‐2H‐chromene‐3‐carboxamides and N‐methoxycinnamamides with benzynes via CH functionalization to synthesize N‐methoxy‐7H‐chromenoquinolinones and N‐methoxyphenylquinolinones has been developed successfully. The reaction demonstrates broad compatibility with different substrates, high tolerance for various functional groups, and excellent regioselectivity. By carefully selecting substituted arynes, exceptional regioselectivity can be achieved. The structure of a key product was confirmed through X‐ray crystallography, further validating the efficiency and success of the reaction.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500107

Authors: Harishankar Behera, Suhasini Mohapatra, Sabita Nayak, Seetaram Mohapatra, Tapaswini Pati, Kamalika Prusty

Institution: Ravenshaw University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Life Sciences Research Board, Science and Engineering Research Board

Awards: G2224824642, G280743645, G2946850294, G8577609105