Work

Some Items of Interest to Process R&D Chemists and Engineers

Year: 2025

Type: editorial

Abstract: Mechanochemistry has been demonstrated to be well-suited for the preparation of organometallic reagents by metal insertion into a carbon-halogen bond.Kubota, Ito, and Kondo from Japan successfully extended the scope of this reaction manifold to encompass organolithium generation from alkyl and aryl halides, including fluorides (Nat.Synth.,

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.5c00215

Authors: James A. Schwindeman, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Annabel Q. Ansel, James M. MacDougall, Elizabeth M. Dauncey, Sylvain Guizzetti, Jimmy Lauberteaux, John Knight

Institutions: Dow Chemical (United States), Janssen Research & Development (United States), Vertex Pharmaceuticals (United Kingdom), Vividion Therapeutics (United States), AstraZeneca (United Kingdom), Sanofi (France)

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4411205852

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