Work

Opening the operating theatre to oncology: treatment of locally recurrent rectal cancer with peritoneal metastasis by simultaneous hyperthermic intraperitoneal chemotherapy and intraoperative electron beam radiotherapy

Year: 2025

Type: article

Abstract: Despite advances in multimodality therapies and surgical technique, locally recurrent rectal cancers (LRRC) and those with peritoneal metastasis (PM) remain challenging for surgeons and oncologists. Although total pelvic exenteration (TPE) and cytoreductive surgery (CRS) for peritoneal disease may enable removal of the main tumour mass and macroscopically visible peritoneal spread, respectively, local recurrence from an R1 resection, and peritoneal recurrence from microscopic peritoneal disease, remain key concerns. Combining radical surgery with oncological adjuncts such as intraoperative electron beam radiotherapy (IOERT), and hyperthermic intraperitoneal chemotherapy (HIPEC), may improve outcomes in this field. Nevertheless the application of both together is poorly reported. Here we describe a case of LRRC with PM treated with TPE and simultaneous HIPEC and IOERT.

Source: Annals of The Royal College of Surgeons of England

DOI: 10.1308/rcsann.2024.0111

Authors: Y Salem, CT West, M West, S Jain, H Yano, J Smith, C Green, A Bateman, A Mirnezami

Institutions: University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, University of Southampton

Language: English

Topic: Colorectal Cancer Surgical Treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411206372

FWCI: 0.373

Cites: 13

Cited by: 1

Related to: 10