Influence of paroxetine (SSRI), cyclooxygenase-2 (COX-2) inhibitor 641784 and their association upon brain haemoglobin (HbO2); an in vivo NIRS analysis
Year: 2024
Type: article
Abstract: The implication of brain oxygenation within brain functions is well known and oxygen is essential to maintaining normal brain functions. Recent studies showed that anaemia is related to an increased risk of depression either in healthy population and in pathological states. Near infrared spectroscopy (NIRS) supplies a non-invasive, non-ionizing way to measure haemoglobin levels and oxygen saturation in the living tissue and is confirmed as valuable tool to monitor influence(s) of acute drug treatment on metabolic activity of the brain. SSRI/COX-2 inhibitor is a recent dual pharmacology approach to treating major depression. In the present work NIRS has been applied to monitor the influence of COX2 inhibitor 641784 (COX2i) or SSRI paroxetine or this COX2i-SSRI association upon HbO2 levels measured in the brain of anaesthetised rodents.
Author: Francesco Crespi
Institution: University of Verona
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411211854