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Antibiotic-conjugated antimicrobial peptides for enhanced bacterial inhibition

Year: 2025
Type: article
Abstract: electrostatic interactions, subsequently disrupting membrane integrity through aggregation and insertion, leading to membrane rupture and cytoplasmic leakage, as evidenced by bacterial morphology studies. Lipopeptides with longer alkyl chains penetrate deeper into the membrane structure, demonstrating stronger antibacterial effects. Additionally, the conjugated antibiotics may enhance bactericidal activity by inhibiting intracellular DNA gyrase. Therapeutic efficacy was further validated in a murine infected wound model. This work not only develops a class of broad-spectrum antimicrobial lipopeptides but also provides a novel strategy for developing antibiotic-conjugated antimicrobial peptides to enhance multiple antibacterial inhibition with minimal side effects.
Source: RSC Advances
DOI: 10.1039/d5ra02932e
Authors: Xingrao Peng, Yong Luo, Tianzhi Xu, Zihan Chen, Peiyao Chen, Cong Hu, Shuang Liu
Institutions: Wuhan University of Technology, Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics, Hubei University of Technology, Guangxi Key Laboratory of Automatic Detecting Technology and Instruments, Guilin University of Electronic Technology
Language: English
Subfield: Microbiology
Open Access status: gold
Estimated APC paid: $1,042
Funders: National Natural Science Foundation of China, Natural Science Foundation of Hubei Province, Hunan University, Guilin University of Electronic Technology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Guangxi Key Laboratory of Automatic Detecting Technology and Instruments, Guilin University of Electronic Technology
OpenAlex ID: W4411214442
FWCI: 3.331
Cites: 56
Cited by: 7
Related to: 10