Work

Response Duration During Treatment of Patients with Follicular Lymphoma

Year: 2025

Type: article

Abstract: Background/Objective: It is known that the duration of response to treatment in patients with follicular lymphoma decreases with advancing lines of treatment. Our current study investigated progression-free survival in patients with follicular lymphoma undergoing different lines of treatment, aiming to understand the factors influencing treatment response and outcomes. Methods: We retrospectively analyzed data from follicular lymphoma patients treated at the University of Debrecen between 2009 and 2023. We collected comprehensive data on patient demographics, disease characteristics, treatment regimens, and outcomes. Results: The analysis included 161 patients with follicular lymphoma. The median follow-up for first-line patients was 51 months (range, 3–204), with a median age of 56 years (range, 25–85). The duration of progression-free survival for the first and second lines coincided, while survival in the third line was indeed an ‘unmet medical need’. Factors that influenced the outcome of the first-line treatment of follicular lymphoma patients have been published before by our working group. A univariate analysis of factors that may have influenced the outcome of second-line treatment was performed. A remarkable impact was found in patients undergoing autologous stem cell transplantations and medium-dose treatment. Another important factor was the presence of B-symptoms at the start of second-line treatment. Conclusions: Our study confirmed the interesting coincidence of the first- and second-line duration of response in follicular lymphoma patients, which can be explained with the high number of patients undergoing stem cell transplantation and medium-dose treatment in the second line.

Source: Biomedicines

DOI: 10.3390/biomedicines13061433

Authors: Evelin Kiss, Árpád Illés, Ádám Jóna

Institution: University of Debrecen

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137