Work

Presumed bilateral endogenous Cryptococcus neoformans endophthalmitis with concomitant Toxoplasma gondii retinochoroiditis

Year: 2025

Type: article

Abstract: Purpose To report a case of bilateral endogenous Cryptococcus endophthalmitis with Toxoplasma retinochoroiditis. Observations A 57-year-old woman with history of renal transplantation developed Cryptococcus neoformans fungemia and meningitis. Reporting bilateral blurry vision, she was found to have associated bilateral endophthalmitis suspicious for endogenous cryptococcal endophthalmitis that was initially responsive to intravitreal voriconazole injections but subsequently worsened despite systemic and intraocular anti-fungal treatments. Given her refractory disease, additional testing was performed, which revealed added infection with Toxoplasma gondii . She underwent bilateral vitrectomy with povidone-iodine infusion and systemic parasiticidal treatment with improvement and stability of her condition. Conclusions and Importance Immunocompromised hosts are at risk for infection with multiple opportunistic infections that may require broad testing and aggressive medical and surgical therapies.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2025.102364

Authors: Shane Griffin, Neeraj Chawla, Lawrence Chan, Anita Agarwal, Gaurav Shah

Institutions: California Pacific Medical Center, West Coast Retina

Language: English

Topic: Ocular Infections and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590