Work

Clinical profile and outcome of children with Neuroblastoma: A single center retrospective study from North India

Year: 2025

Type: article

Abstract: ABSTRACT Background With the advancement of pediatric oncology care, the outcome of children with neuroblastoma has improved remarkably. However, in low and middle-income countries (LMICs), the survival rate is still poor. This study was conducted because of the paucity of data regarding the clinico-epidemiological profile and outcome of children with neuroblastoma in India. Methods Children (<13 y) with neuroblastoma treated at our centre between 2016 and 2022 were retrospectively analyzed. Results Over the 7-year study period, 53 children with neuroblastoma were treated at our centre. The age ranged from 1 month to 13 years (male: female ratio: 2.3:1). Adrenal was the most common primary site (58%). The majority of children had stage 4 disease (58.5%). The projected 2-year overall survival is 30%, whereas the event-free survival is 24.5%. Conclusions Children with neuroblastoma in our setting present late with advanced disease. Even with a multidisciplinary approach, the survival rates of patients with advanced disease are still poor in our setting.

Source: Pediatric Hematology Oncology Journal

DOI: 10.1016/j.phoj.2025.100466

Authors: Zaibaish Khan, Nishant Verma

Institution: King George's Medical University

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600