Variable Selection with FDR Control for Noisy Data – An Application to Screening Metabolites that Are Associated with Breast Cancer and Colorectal Cancer
Year: 2025
Type: article
Abstract: The rapidly expanding field of metabolomics presents an invaluable resource for understanding the associations between metabolites and various diseases. However, the high dimensionality, presence of missing values, and measurement errors associated with metabolomics data can present challenges in developing reliable and reproducible approaches for disease association studies. Therefore, there is a compelling need for robust statistical analyses that can navigate these complexities to achieve reliable and reproducible disease association studies. In this paper, we construct algorithms to perform variable selection for noisy data and control the False Discovery Rate when selecting mutual metabolomic predictors for multiple disease outcomes. We illustrate the versatility and performance of this procedure in a variety of scenarios, dealing with missing data and measurement errors. As a specific application of this novel methodology, we target two of the most prevalent cancers among US women: breast cancer and colorectal cancer. By applying our method to the Women's Health Initiative data, we successfully identify metabolites that are associated with either or both of these cancers, demonstrating the practical utility and potential of our method in identifying consistent risk factors and understanding shared mechanisms between diseases.
Source: Journal of Data Science
DOI: 10.6339/25-jds1166
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: diamond
Awards: G1050918383, G1471908156, G1610933967, G1851278524, G2209176514, G2239996411, G2367098337, G3062349281, G3069585042, G339659072, G3526771996, G3643850837, G3900787601, G4266498966, G4546180501, G4660785451, G4908813673, G6694253514, G700120080, G7078062614, G7332203415, G757750085, Nutrition and Physical Activity Assessment Study - Assessment of Dietary Supplements, G8606882599, G9000020404, G9000085113, G9000131833, G9000136283, Cancer Center Support Grant, G915959914
OpenAlex ID: W4411221682