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Two-year follow-up of patients with myocardial injury during acute COVID-19: insights from the CARDIO COVID 20–21 registry

Year: 2025

Type: article

Abstract: Introduction COVID-19 can cause Myocardial Injury (MI) during acute illness, which has been strongly associated with worse outcomes during hospitalization, however, more research is required on its effects on long-term outcomes, especially in underexplored regions in the literature such as Latin America. Methods This multicenter prospective cohort study follows up with patients with previous severe COVID-19 at a 2-year follow-up encounter. Comprehensive assessments were conducted including demographic data, clinical variables, psychiatric evaluations, and echocardiographic studies. Patients were stratified by the presence or absence of MI during their acute COVID-19 hospitalization. Statistical analyses included logistic regression and univariate comparisons. Results Of the 210 patients included, 53 (25%) had MI. Patients with MI were older, had a higher prevalence of comorbidities (e.g., hypertension, chronic kidney disease, atrial fibrillation), and were more likely to require intensive care unit admission, invasive mechanical ventilation, and vasopressor or inotropic support during acute COVID-19. Regarding long-term cardiovascular outcomes, no significant differences were observed in de novo cardiovascular disease, venous thromboembolism, or acute cardiovascular events. Patients with MI had greater odds of cardiopulmonary hospitalizations during follow-up (aOR 3.67, 95% CI 1.07–13.07, p = 0.037) after adjusting for age and sex. Conclusion Patients with prior MI during COVID-19 had a higher prevalence of comorbidities, poorer functional status, and increased odds of cardiopulmonary hospitalizations over a two-year follow-up evaluation compared to those without MI. Although prior studies suggest an association between MI and worse long-term outcomes, the evidence remains inconsistent. These findings emphasize the need for ongoing research to clarify how MI contributes to worsened long-term outcomes.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1584732