Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice
Year: 2025
Type: article
Abstract: Spinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation, effective wound healing, and the regulation of neuronal plasticity. Here, we identify the role of the actin-binding protein Drebrin (DBN) in reactive astrogliosis following SCI. SCI induces the upregulation of DBN in astrocytes, which controls immediate injury containment but also the long-term preservation of tissue integrity and healing in the spinal cord. DBN knockout results in enlarged spinal cord lesions, increased immune cell infiltration, and neurodegeneration. Mechanistically, DBN loss disrupts the polarization of scar border-forming astrocytes, leading to impaired encapsulation of the injury. In summary, DBN serves as a pivotal regulator of SCI outcome by modulating astrocytic polarity, which is essential for establishing a protective barrier confining the lesion site.
Source: Glia
DOI: 10.1002/glia.70048
Language: English
Topic: Spinal Cord Injury Research
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,450
Awards: G1629711691, G1680808902, G1717570230, G1751328538, G1923547659, G1935710221, G202409988, National Infrastructure for Biological and Medical Imaging, G23348962, IMatrix - Therapeutisches Targeting von extrazellulären Matrix-Metalloproteinasen und Störungen der Blut-Hirn-Schranke bei subakutem ischämischem Schlaganfall, G244984603, G2572698527, G2589556207, G3011267836, G301705488, G3130636412, Nanomaterials and Nanotechnologies for Environment Protection and Sustainable Future, Czech Centre for Phenogenomics, G3606913474, G3622461675, G3810236772, G3863918630, G3891910667, G4396925471, G4510041740, G4857714998, Gestaltung der GliaNarbe während einer ZNSVerletzung durch Manipulation des AktinZytoskeletts in Astrozyten, G5080845649, G5159295391, G5358030738, G5511180595, G5641063287, TRR 295: Behandlung motorischer Netzwerkstörungen mittels Neuromodulation, EXC 2049: Comprehensive approaches to neurological and psychiatric disorders "NeuroCure", G6170230151, G6219790147, G6392114090, G6798159547, G6887403513, G709394430, G7537243769, G8140083606, G8887772741, G965965765
OpenAlex ID: W4411224483