Retroauricular subperiosteal vs systemic intravenous glucocorticoid administration on efficacy and blood glucose in diabetic patients with sudden deafness
Year: 2025
Type: article
Abstract: BACKGROUND Managing sudden deafness (SD) in patients with diabetes mellitus (DM) is particularly challenging due to the heightened risk of adverse effects associated with systemic drug administration. This study explores the potential of retroauricular subperiosteal injection as a localized drug delivery method for a more effective and safe treatment. AIM To compare the efficacy of retroauricular subperiosteal injection vs systemic intravenous glucocorticoid (GC) administration for SD in patients with DM and assess the effects on blood glucose levels. METHODS A total of 128 cases of type 2 DM (T2DM) with SD diagnosed and treated in Zibo Central Hospital from February 2021 to July 2023 were divided into two groups: An observation group (66 cases receiving retroauricular subperiosteal injection of methylprednisolone) and a control group (62 cases receiving systemic intravenous administration of methylprednisolone). The two groups were compared in terms of therapeutic efficacy, hearing recovery, blood glucose level changes, and incidence of adverse reactions. Binary logistic regression was used to analyze the factors affecting therapeutic efficacy. RESULTS The observation group showed a significantly higher total effective rate (90.91%) compared with the control group (75.81%, P < 0.05). Additionally, pure-tone hearing threshold, fasting plasma glucose, and 2-hour postprandial blood glucose were significantly lower in the observation group compared with the control group (P < 0.05). The incidence of adverse reactions was also lower in the observation group than in the control group (7.58% vs 22.58%, P < 0.05). A T2DM course longer than 5 years and systemic intravenous GC administration were identified as independent risk factors for treatment inefficacy (P < 0.05). CONCLUSION In treating patients with diabetes and SD, retroauricular subperiosteal injection of methylprednisolone offers superior therapeutic efficacy and lower incidence of adverse reactions compared with systemic intravenous GC administration, with minimal impact on blood glucose.
Source: World Journal of Diabetes
Authors: Juan Long, Hong-Wei Zuo
Institution: Central Hospital of Zibo
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411226776