Work

The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis

Year: 2025

Type: article

Abstract: G-protein coupled receptors (GPCRs) are key regulators in coordinating environmental sensing with intracellular responses.While their roles in signaling and development are well understood in mammals, fungal GPCRs remain largely unexplored.Key information on receptor classification, ligand activation, and G-protein interactions is still limited.However, recent advances in combining genomics, metagenomics, and synthetic biology with structural biology-especially structure prediction and cryo-electron microscopy (cryo-EM) -are opening new avenues for studying fungal GPCRs.In this review, we highlight recent discoveries on how GPCRs mediate fungal interactions, explore their potential roles in complex microbial communities, and suggest future research directions in this emerging field.

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1013212

Authors: Max Heinen, Hanna Rovenich, Florian Altegoer

Institutions: Cluster of Excellence on Plant Sciences, Heinrich Heine University Düsseldorf, University of Cologne

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,043

Funder: Deutsche Forschungsgemeinschaft