Correlation between human papillomavirus infection and vaginal microecological environment, and the effect of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on human papillomavirus infection.
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: This study mainly analyzed the correlation between human pap-illomavirus infection (HPV) and vaginal microecological environment and ex-plored the effect of Lactobacillus vaginal capsule combined with recombinant human interferon α-2b gel on HPV infection. Five hundred patients who un-derwent a gynecological examination in our hospital from June 2021 to June 2023 were selected and divided into HPV-positive and HPV-negative groups. Relative to the HPV-negative group, the HPV-positive group presented a higher abnormal rate of Lactobacillus, catalase, cleanliness, neuraminidase and pro-line aminopeptidase (p<0.05) and a higher positive rate of bacterial vaginosis (BV) (p<0.05). Multivariate logistic regression analysis showed that catalase, proline aminopeptidase and BV were risk factors for HPV infection (p<0.05). In addition, 180 HPV-positive patients were randomly divided into a control group (CG) and an observation group (OG). The CG was given recombinant human interferon α-2b gel, and the OG was treated with recombinant human inter-feron α-2b gel plus a Lactobacillus vaginal capsule. Relative to the CG, the OG presented a higher total effective rate (p<0.05), lower inflammation (p<0.01), better immune function (p<0.01), and a higher proportion of grade II-III vagi-nal flora density and grade II-III vaginal flora diversity (p<0.001). Collectively, HPV is significantly correlated with the vaginal microecological environment, and catalase, proline aminopeptidase and BV were closely related to HPV infec-tion. In addition, Lactobacillus vaginal capsule plus recombinant human inter-feron α-2b gel has practical clinical efficacy, which can reduce inflammation, promote immune function, improve vaginal microecological environment, and is safe in the treatment of patients with HPV infection.
Source: Investigación Clínica
DOI: 10.54817/ic.v66n2a01
Authors: Yanling Sun, Li Li, Wenxin Xu, Cen Ma
Institution: First Affiliated Hospital of Soochow University
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4411238890