Correlation between thyroid hormone values and anemia in elderly patients with diabetic nephropathy.
Year: 2025
Type: article
Study design: Observational Study
Abstract: We aimed to explore the correlation between thyroid hormone levels and anemia severity in elderly diabetic nephropathy (DN) patients.Elder-ly DN patients (140 in total) diagnosed and treated during November 2019 and December 2023 were retrospectively recruited as a DN group, 140 patients with uncomplicated diabetes mellitus as a simple diabetes group, and 140 healthy subjects as a healthy group. A non-anemia group (n=63) and an anemia group (n=77) were set up as sets of the DN group according to the hemoglobin (Hb) level, and the anemia group was further divided into a severe group (n=48) (Hb<60 g/L), a moderate group (n=16) (60 g/L≤Hb<90 g/L) and a mild group (n=13) (Hb≥90 g/L). Compared to the simple diabetes group, signifi-cantly increased levels of serum TSH and significantly decreased levels of FT4 and FT3 were found in the DN group (p<0.05). A significant increase in TSH levels and significant decreases in FT4 and FT3 levels were detected in the serum from the moderate group compared with those from the mild group (p<0.05). The same trends in these levels were observed from the severe group compared to the moderate group (p<0.05). Hb had a negative correlation with TSH and positive correlations with FT4 and FT3 (p<0.05). High TSH and low FT4 and FT3 may be related to anemia in elderly patients with DN, and they have correlations with the severity of anemia.
Source: Investigación Clínica
DOI: 10.54817/ic.v66n2a03
Authors: Jingjing Yu, Keke Tang, Yan Song
Institution: Ningbo University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411239603