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Transgenerational diabetogenic effects of preconception exposure to inorganic arsenic in C57BL/6 mice are associated with dysregulation of DNA methylation and gene expression in G1 and G2 offspring

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Year: 2025
Type: article
Source: Archives of Toxicology
DOI: 10.1007/s00204-025-04107-y
Authors: Bingzhen Shang, Tianyi Liu, Hadley Hartwell, Christelle Douillet, Abhishek Venkatratnam, Shi Qing, Madison Miller, Fei Zou, Sergey A. Krupenko, Folami Y. Ideraabdullah, Fernando Pardo-Manuel de Villena, Rebecca C. Fry, Miroslav Stýblo
Institution: University of North Carolina at Chapel Hill
Language: English

Topic: Epigenetics and DNA Methylation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Environmental Health Sciences
Awards: Environmental arsenic and diabetes mellitus, Mechanisms of Arsenic-Induced Diabetes Mellitus, G2009978684, Developmental windows for arsenic-associated diabetes, Genetic underpinning of diabetes associated with arsenic exposure, Humanized mouse models for arsenic toxicology, The UNC Chapel Hill Superfund Research Program (UNC-SRP)
OpenAlex ID: W4411248084
FWCI: 0.896
Cites: 79
Cited by: 3
Related to: 10
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