Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Marine cyanobacteria are a rich source of structurally diverse compounds with biological activity. Herein, we report the total synthesis of kavaratamide A ( 1 ), a bioactive lipodepsipeptide isolated from Moorena bouillonii . The total synthesis of 1 required 16 steps, with a longest linear sequence of 9 steps, and an overall yield of 2.9%. Our convergent synthetic approach led to the efficient synthesis of kavaratamide A–C, C25- epi- kavaratamide A, and deoxy-kavaratamide A from a common intermediate providing a blueprint for facilitating rapid structure–activity relationship (SAR) studies.
Source: ACS Omega
Authors: Tomayo I. Berida, Craig W. Lindsley
Institution: Vanderbilt University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Funder: William K. Warren Foundation
OpenAlex ID: W4411256171