Building Trust in Clinical AI: A Web-Based Explainable Decision Support System for Chronic Kidney Disease.
Year: 2025
Type: article
Abstract: Chronic Kidney Disease (CKD) is a significant global public health issue, affecting over 10% of the population. Timely diagnosis is crucial for effective management. Leveraging machine learning within healthcare offers promising advancements in predictive diagnostics. We developed a Web-Based Clinical Decision Support System (CDSS) for CKD, incorporating advanced Explainable AI (XAI) methods, specifically SHAP (Shapley Additive Explanations) and LIME (Local Interpretable Model-agnostic Explanations). The model employs and evaluates multiple classifiers: KNN, Random Forest, AdaBoost, XGBoost, CatBoost, and Extra Trees, to predict CKD. The effectiveness of the models is assessed by measuring their accuracy, analyzing confusion matrix statistics, and the AUC. AdaBoost achieved a 100% accuracy rate. Except for KNN, all classifiers consistently reached perfect precision and sensitivity. Additionally, we present a real-time web-based application to operationalize the model, enhancing trust and accessibility for healthcare practitioners and stakeholder.
Source: PubMed
Authors: Krishna Mridha, Ming Wang, Lijun Zhang
Institution: Case Western Reserve University
Language: English
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4411256723